Overview

  • Product name
    Anti-SYT homolog 1 antibody
    See all SYT homolog 1 primary antibodies
  • Description
    Rabbit polyclonal to SYT homolog 1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 200-383 of Human SYT homolog 1 (O75177).

  • Positive control
    • MCF7 whole cell lysates.
  • General notes
    Keep as a concentrated solution.

Properties

Applications

Our Abpromise guarantee covers the use of ab126126 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 43 kDa.

Target

  • Function
    Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP.
  • Tissue specificity
    Ubiquitous; with lowest levels in spleen.
  • Sequence similarities
    Belongs to the SS18 family.
  • Domain
    The MFD (multi-functional domain) domain is involved in transcription transactivation, nuclear body targeting and dimerization.
  • Cellular localization
    Nucleus. Chromosome > centromere > kinetochore. Localizes to nuclear bodies. Co-localizes with SGOL1 at kinetochore.
  • Information by UniProt
  • Database links
  • Alternative names
    • Calcium-responsive transactivator antibody
    • CREST antibody
    • CREST_HUMAN antibody
    • KIAA0693 antibody
    • LP2261 antibody
    • MGC26711 antibody
    • MGC78386 antibody
    • sarcoma translocation gene on chromosome18like1 antibody
    • SS18 antibody
    • SS18-like protein 1 antibody
    • SS18L1 antibody
    • SS18L1 nBAF chromatin remodeling complex antibody
    • SSXT antibody
    • synovial sarcoma translocation antibody
    • synovial sarcoma translocation gene on chromosome 18-like 1 antibody
    • SYT homolog 1 antibody
    see all

Images

  • Anti-SYT homolog 1 antibody (ab126126) at 1/1000 dilution + MCF7 whole cell lysate at 30 µg

    Predicted band size : 43 kDa

References

ab126126 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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