Overview

  • Product name
  • Description
    Rabbit polyclonal to SYVN1
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 550 - 600 of SYVN1 (NP_757385.1).

  • Positive control
    • HeLa whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab104495 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-5 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
    • Tissue specificity
      Ubiquitously expressed, with highest levels in liver and kidney (at protein level). Up-regulated in synovial tissues from patients with rheumatoid arthritis (at protein level).
    • Pathway
      Protein modification; protein ubiquitination.
    • Sequence similarities
      Belongs to the HRD1 family.
      Contains 1 RING-type zinc finger.
    • Domain
      The RING-type zinc finger is required for E3 ligase activity.
    • Post-translational
      modifications
      Not N-glycosylated.
      Auto-ubiquitinated.
    • Cellular localization
      Endoplasmic reticulum membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • 1200010C09Rik antibody
      • DER3 antibody
      • E3 ubiquitin-protein ligase synoviolin antibody
      • HMG coA reductase degradation 1 homolog antibody
      • HRD1 antibody
      • KIAA1810 antibody
      • MGC40372 antibody
      • OTTHUMP00000230429 antibody
      • OTTHUMP00000230430 antibody
      • OTTHUMP00000230431 antibody
      • OTTHUMP00000230432 antibody
      • Synovial apoptosis inhibitor 1 antibody
      • Synovial apoptosis inhibitor 1, synoviolin antibody
      • Synoviolin 1 antibody
      • Synoviolin 1 isoform b antibody
      • SYNOVIOLIN antibody
      • SYVN1 antibody
      • SYVN1_HUMAN antibody
      see all

    References

    ab104495 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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