Mouse, Human Predicted to work with:
Horse, Cow, Dog, Chimpanzee, Macaque monkey
Recombinant fragment: LGAPRDHSYE AEFRAVSMKP AFLPSAPGPT MSYYRGQEVL APGAGWPVAP QYPPKMGPAS WFRPMRTLPM EPGPGGSEGR GPEDQGPPLV WTEIAPIRPE , corresponding to amino acids 387-486 of Human T-bet/ Tbx21 (AAH39739) with a proprietary tag
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 58 kDa.
Use at an assay dependent dilution.
FunctionTranscription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.
Tissue specificityT-cell specific.
Involvement in diseaseGenetic variations in TBX21 are associated with susceptibility to asthma with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]. A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities.
Anti-T-bet / Tbx21 antibody (ab88114) at 1 µg/ml + NIH 3T3 cell lysate at 25 µg
Secondary Goat anti-Mouse IgG at 1/5000 dilution
Predicted band size : 58 kDa
References for Anti-T-bet / Tbx21 antibody (ab88114)
This product has been referenced in:
Singh SP et al. Prenatal secondhand cigarette smoke promotes Th2 polarization and impairs goblet cell differentiation and airway mucus formation. J Immunol187:4542-52 (2011).
Read more (PubMed: 21930963) »
Yang P et al. The mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers. Int J Immunogenet37:111-5 (2010).
Read more (PubMed: 20193034) »