• Product nameAnti-T-bet / Tbx21 antibody
    See all T-bet / Tbx21 primary antibodies
  • Description
    Mouse monoclonal to T-bet / Tbx21
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Horse, Cow, Dog, Chimpanzee, Macaque monkey
  • Immunogen

    Recombinant fragment: LGAPRDHSYE AEFRAVSMKP AFLPSAPGPT MSYYRGQEVL APGAGWPVAP QYPPKMGPAS WFRPMRTLPM EPGPGGSEGR GPEDQGPPLV WTEIAPIRPE , corresponding to amino acids 387-486 of Human T-bet/ Tbx21 (AAH39739) with a proprietary tag

  • Positive control
    • NIH 3T3 cell lysate



Our Abpromise guarantee covers the use of ab88114 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 58 kDa.
ELISA Use at an assay dependent dilution.


  • FunctionTranscription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.
  • Tissue specificityT-cell specific.
  • Involvement in diseaseGenetic variations in TBX21 are associated with susceptibility to asthma with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]. A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities.
  • Sequence similaritiesContains 1 T-box DNA-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • T bet antibody
    • T box 21 antibody
    • T box expressed in T cells antibody
    • T box protein 21 antibody
    • T box transcription factor TBX21 antibody
    • T cell specific T box transcription factor antibody
    • T cell specific T box transcription factor T bet antibody
    • T PET antibody
    • T-box protein 21 antibody
    • T-box transcription factor TBX21 antibody
    • T-cell-specific T-box transcription factor T-bet antibody
    • TBET antibody
    • TBLYM antibody
    • TBX 21 antibody
    • Tbx21 antibody
    • TBX21_HUMAN antibody
    • TPET antibody
    • Transcription factor TBLYM antibody
    see all

Anti-T-bet / Tbx21 antibody images

  • Anti-T-bet / Tbx21 antibody (ab88114) at 1 µg/ml + immunogen (tagged recombinant fragment) at 0.2 µg

    Goat anti-Mouse IgG at 1/5000 dilution

    Predicted band size : 58 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)
  • Anti-T-bet / Tbx21 antibody (ab88114) at 1 µg/ml + NIH 3T3 cell lysate at 25 µg

    Goat anti-Mouse IgG at 1/5000 dilution

    Predicted band size : 58 kDa

References for Anti-T-bet / Tbx21 antibody (ab88114)

This product has been referenced in:
  • Singh SP  et al. Prenatal secondhand cigarette smoke promotes Th2 polarization and impairs goblet cell differentiation and airway mucus formation. J Immunol 187:4542-52 (2011). WB ; Mouse . Read more (PubMed: 21930963) »
  • Yang P  et al. The mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers. Int J Immunogenet 37:111-5 (2010). Read more (PubMed: 20193034) »

See all 2 Publications for this product

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