Overview

  • Product nameT0070907
  • Description
    Potent, selective PPARγ antagonist
  • Biological descriptionPotent, selective PPARγ antagonist (IC50 = 1 nM). Antidiabetic actions in vivo. Inhibits rosiglitazone (ab120762). Blocks the recruitment of transcriptional cofactors to the PPARγ/RXR heterodimer.
  • Purity> 98%

Properties

    References for T0070907 (ab120876)

    This product has been referenced in:
    • Schaefer KL  et al. Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells. Cancer Res 65:2251-9 (2005). Read more (PubMed: 15781638) »
    • Rockwell CE & Kaminski NE A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. J Pharmacol Exp Ther 311:683-90 (2004). Read more (PubMed: 15284281) »
    • Lee G  et al. T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem 277:19649-57 (2002). Read more (PubMed: 11877444) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"