Overview

  • Product name
    Anti-TA1 antibody - N-terminal
    See all TA1 primary antibodies
  • Description
    Rabbit polyclonal to TA1 - N-terminal
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Horse, Cat, Chimpanzee, Monkey, Common marmoset, Orangutan
  • Immunogen

    Synthetic peptide within Human TA1 (N terminal). The exact sequence is proprietary. 16 amino acid peptide.
    Database link: Q96RJ0

  • Positive control
    • Human brain amygdala tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab189016 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 1.3 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function
    Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
  • Tissue specificity
    Detected in low levels in discrete regions within the central nervous system and in several peripheral tissues. Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small intestine. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation, prostate, skeletal muscle and spleen.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Taar1 antibody
    • TAAR1_HUMAN antibody
    • TaR-1 antibody
    • Trace amine associated receptor 1 antibody
    • Trace amine receptor 1 antibody
    • Trace amine-associated receptor 1 antibody
    • Trar1 antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin embedded human brain amygdala tissue labeling TA1 using ab189016 at 1.3 µg/ml.

References

ab189016 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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