Overview

  • Product nameAnti-TAB2 antibody
    See all TAB2 primary antibodies
  • Description
    Goat polyclonal to TAB2
  • Tested applicationsIHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide:

    C-NLDLQSQNIYHH

    with a Cysteine residue linker, corresponding to amino acids 79-90 of Human TAB2 (NP_055908.1).

  • Positive control
    • Human colon tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab118485 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3.75 - 7.5 µg/ml.

Target

  • FunctionAdapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.
  • Tissue specificityWidely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
  • Involvement in diseaseDefects in TAB2 are the cause of congenital heart disease non-syndromic type 2 (CHTD2) [MIM:612863]. It is a disease characterized by congenital developmental abnormalities involving structures of the heart. Clinical features include left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. Note=A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25).
  • Sequence similaritiesContains 1 CUE domain.
    Contains 1 RanBP2-type zinc finger.
  • Post-translational
    modifications
    Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation.
    Phosphorylated.
  • Cellular localizationMembrane. Cytoplasm > cytosol. Following IL1 stimulation, translocation occurs from the membrane to cytosol.
  • Information by UniProt
  • Database links
  • Alternative names
    • CHTD2 antibody
    • FLJ21885 antibody
    • KIAA0733 antibody
    • MAP3K7IP2 antibody
    • Mitogen activated protein kinase kinase kinase 7 interacting protein 2 antibody
    • Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 antibody
    • OTTHUMP00000040125 antibody
    • TAB 2 antibody
    • TAB-2 antibody
    • Tab2 antibody
    • TAB2_HUMAN antibody
    • TAK1 binding protein 2 antibody
    • TAK1-binding protein 2 antibody
    • TGF beta activated kinase 1/MAP3K7 binding protein 2 antibody
    • TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 antibody
    • TGF-beta-activated kinase 1-binding protein 2 antibody
    see all

Anti-TAB2 antibody images

  • ab118485 at 7.5µg/ml staining TAB2 in Formalin-fixed, Paraffin-embedded Human colon tissue by immunohistochemistry.

References for Anti-TAB2 antibody (ab118485)

ab118485 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"