Anti-TAB2 antibody (ab153882)
Key features and details
- Rabbit polyclonal to TAB2
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-TAB2 antibody
See all TAB2 primary antibodies -
Description
Rabbit polyclonal to TAB2 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse
Predicted to work with: Human -
Immunogen
Recombinant fragment, corresponding to a region within amino acids 17-296 of Human TAB2.
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Positive control
- NIH3T3 whole cell lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab153882 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 76 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 76 kDa. |
Target
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Function
Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. -
Tissue specificity
Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. -
Involvement in disease
Defects in TAB2 are the cause of congenital heart disease non-syndromic type 2 (CHTD2) [MIM:612863]. It is a disease characterized by congenital developmental abnormalities involving structures of the heart. Clinical features include left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. Note=A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25). -
Sequence similarities
Contains 1 CUE domain.
Contains 1 RanBP2-type zinc finger. -
Post-translational
modificationsUbiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation.
Phosphorylated. -
Cellular localization
Membrane. Cytoplasm > cytosol. Following IL1 stimulation, translocation occurs from the membrane to cytosol. - Information by UniProt
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Database links
- Entrez Gene: 23118 Human
- Entrez Gene: 68652 Mouse
- Omim: 605101 Human
- SwissProt: Q9NYJ8 Human
- SwissProt: Q99K90 Mouse
- Unigene: 269775 Human
- Unigene: 193041 Mouse
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Alternative names
- CHTD2 antibody
- FLJ21885 antibody
- KIAA0733 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab153882 has been referenced in 2 publications.
- Zhou Q et al. USP15 potentiates NF-κB activation by differentially stabilizing TAB2 and TAB3. FEBS J 287:3165-3183 (2020). PubMed: 31903660
- Liu S et al. Hydroxysafflor Yellow A Inhibits TNF-a-Induced Inflammation of Human Fetal Lung Fibroblasts via NF-?B Signaling Pathway. Evid Based Complement Alternat Med 2019:4050327 (2019). PubMed: 31949467