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Products:Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> MAPK Pathway
Overview
Product name
Anti-TAB3 antibody
See all TAB3 products (4) ...
Description
Rabbit polyclonal to TAB3
Tested applications
Cross reactivity
Reacts with
Mouse, Dog, Human
Predicted to work with
Chicken, Cow, Opossum
Immunogen
Synthetic peptide (Human) corresponding to a region between residues 50-100 of human TAB3. (The immunogen sequence is 100% homologous in both human isoforms).
Positive control
Human kidney lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 0.2% Gelatin, PBS
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Polyclonal
Isotype
IgG
-
Western blot - Anti-TAB3 antibody (ab72125)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab72125 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 0.5 - 2 µg/ml.Detects a band of approximately 79 kDa (predicted molecular weight: 79 kDa).
Target
Function
Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
Tissue specificity
Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.
Sequence similarities
Contains 1 CUE domain.
Contains 1 RanBP2-type zinc finger.
Post-translational
modifications
Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.
Target information above from: UniProt accessionQ8N5C8
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- MAP3K7IP 3 antibody
- Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 antibody
- NAP1 antibody
see all
Database links
- Entrez Gene: 257397 Human
- Entrez Gene: 66724 Mouse
- Omim: 300480 Human
- SwissProt: Q8N5C8 Human
- SwissProt: Q571K4 Mouse
- Unigene: 188256 Human
- Unigene: 119646 Mouse
Anti-TAB3 antibody images:
Western blot - Anti-TAB3 antibody (ab72125)
All lanes : Anti-TAB3 antibody (ab72125) at 0.5 µg/ml
Lane 1 : Human kidney lysate
Lane 2 : Human kidney lysate plus immunising peptide
Predicted band size : 79 kDa
Observed band size : 79 kDa
References for Anti-TAB3 antibody (ab72125)
ab72125 has not yet been referenced specifically in any publications.
Publishing research using ab72125? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"