The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000 - 1/10000. Detects a band of approximately 90 kDa (predicted molecular weight: 79 kDa).
Application notesIs unsuitable for Flow Cyt,IHC-P or IP.
FunctionAdapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
Tissue specificityWidely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.
References for Anti-TAB3 antibody [EPR5965] (ab124723)
This product has been referenced in:
Hu MM et al. TRIM38 inhibits TNFa- and IL-1ß-triggered NF-?B activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A111:1509-14 (2014).
Read more (PubMed: 24434549) »