Overview

  • Product nameAnti-TAB3 antibody [EPR5965]
    See all TAB3 primary antibodies
  • Description
    Rabbit monoclonal [EPR5965] to TAB3
  • Tested applicationsSuitable for: WB, ICC/IFmore details
    Unsuitable for: Flow Cyt,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Human
    Does not react with: Rat
  • Immunogen

    A synthetic peptide corresponding to residues in Human TAB3.

  • Positive control
    • HepG2 cells; 293T, HepG2, HeLa, Caco-2, RAW264.7 and NIH 3T3 cell lysates.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Properties

Applications

Our Abpromise guarantee covers the use of ab124723 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 90 kDa (predicted molecular weight: 79 kDa).
ICC/IF 1/50.
  • Application notesIs unsuitable for Flow Cyt,IHC-P or IP.
  • Target

    • FunctionAdapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
    • Tissue specificityWidely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.
    • Sequence similaritiesContains 1 CUE domain.
      Contains 1 RanBP2-type zinc finger.
    • Post-translational
      modifications
      Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.
    • Information by UniProt
    • Database links
    • Alternative names
      • MAP3K7IP 3 antibody
      • Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 antibody
      • NAP1 antibody
      • NF-kappa-B-activating protein 1 antibody
      • NFkB activating protein 1 antibody
      • TAB-3 antibody
      • Tab3 antibody
      • TAB3_HUMAN antibody
      • TAK1 binding protein 3 antibody
      • TAK1-binding protein 3 antibody
      • TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 antibody
      • TGF-beta-activated kinase 1-binding protein 3 antibody
      see all

    Anti-TAB3 antibody [EPR5965] images

    • All lanes : Anti-TAB3 antibody [EPR5965] (ab124723) at 1/1000 dilution

      Lane 1 : 293T cell lysate
      Lane 2 : HepG2 cell lysate
      Lane 3 : HeLa cell lysate
      Lane 4 : Caco-2 cell lysate
      Lane 5 : RAW264.7 cell lysate
      Lane 6 : NIH 3T3 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 79 kDa
    • ab124723, at 1/50 dilution, staining TAB3 in HepG2 cells by Immunofluorescence.
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References for Anti-TAB3 antibody [EPR5965] (ab124723)

    This product has been referenced in:
    • Hu MM  et al. TRIM38 inhibits TNFa- and IL-1ß-triggered NF-?B activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A 111:1509-14 (2014). Read more (PubMed: 24434549) »

    See 1 Publication for this product

    Product Wall

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"