Overview

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    pH: 8.00
    Preservative: 0.05% Sodium azide
    Constituents: 2.42% Tris, 0.0292% EDTA, 30% Glycerol, 8.7% Sodium chloride
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab17915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP
WB
  • Application notes
    IP: Use at an assay dependent dilution.
    WB: Use at a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 125 and 55 kDa (predicted molecular weight: 90 kDa, there are several other isoforms).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
    • Tissue specificity
      Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.
    • Sequence similarities
      Belongs to the TACC family.
      Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains.
    • Developmental stage
      Expressed at high level during early embryogenesis.
    • Post-translational
      modifications
      Isoform 1 is heavily phosphorylated; isoform 6 is not. Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization
      Cytoplasm. Nucleus. Cytoplasm > cytoskeleton > centrosome. Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis.
    • Information by UniProt
    • Database links
    • Alternative names
      • DKFZp686K18126 antibody
      • Ga 55 antibody
      • Ga55 antibody
      • Gastric cancer antigen Ga 55 antibody
      • Gastric cancer antigen Ga55 antibody
      • KIAA1103 antibody
      • TACC 1 antibody
      • Tacc1 antibody
      • TACC1_HUMAN antibody
      • Taxin 1 antibody
      • Taxin-1 antibody
      • Taxin1 antibody
      • Transforming acidic coiled coil containing protein 1 antibody
      • Transforming acidic coiled-coil-containing protein 1 antibody
      see all

    References

    ab17915 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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