The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesIHC-P: 1/100 - 1/500.
Antigen exposure is recommended.
Antigen exposure with citrate buffer will enhance staining.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionRNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).
Tissue specificityUbiquitous. Observed in all fetal and adult tissues.
Involvement in diseaseNote=A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3.
Sequence similaritiesBelongs to the RRM TET family. Contains 1 RanBP2-type zinc finger. Contains 1 RRM (RNA recognition motif) domain.
Post-translational modificationsDimethylated by PRMT1 at Arg-206 to asymmetric dimethylarginine. The methylation may favor nuclear localization and positive regulation of TAF15 transcriptional activity. Phosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localizationNucleus. Cytoplasm. Shuttles from the nucleus to the cytoplasm.
ab84369 at 1/250, staining human TAF15 in a section of human stomach adenocarcinoma by immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Detection: DAB staining using anti-rabbit antibody at 1/100.
References for Anti-TAF15 antibody (ab84369)
has not yet been referenced specifically in any publications.
Publishing research using ab84369? Please let us know so that we can cite the reference in this datasheet.
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