Overview

  • Product nameAnti-TAK1 antibody
    See all TAK1 primary antibodies
  • Description
    Rabbit polyclonal to TAK1
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Sheep, Rabbit, Guinea pig, Hamster, Cow, Dog, Pig, Xenopus laevis, Monkey, Zebrafish
  • Immunogen

    Synthetic peptide:

    KQLEVIRSQQQKRQGTS

    conjugated to KLH by a Cysteine residue linker, corresponding to amino acids 563-579 of Mouse TAK1

  • Positive control
    • Human tonsil, prostate and placenta tissues.
  • General notesFor maximum product recovery, after thawing, centrifuge the product vial before removing cap.

Properties

Applications

Our Abpromise guarantee covers the use of ab111096 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 67 kDa.
IHC-P Use a concentration of 5 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionComponent of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.
  • Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Association with TAB1/MAP3K7IP1 promotes autophosphorylation and subsequent activation. Association with TAB2/MAP3K7IP2, itself associated with free unanchored Lys-63 polyubiquitin chain, promotes autophosphorylation and subsequent activation of MAP3K7. Dephosphorylation at Thr-187 by PP2A and PPP6C leads to inactivation.
    Ubiquitinated, leading to proteasomal degradation (By similarity). Requires 'Lys-63'-linked polyubiquitination for autophosphorylation and subsequent activation. 'Lys-63'-linked ubiquitination does not lead to proteasomal degradation. Deubiquitinated by CYLD, a protease that selectively cleaves 'Lys-63'-linked ubiquitin chains. Deubiquitinated by Y.enterocolitica YopP.
  • Information by UniProt
  • Database links
  • Alternative names
    • M3K7_HUMAN antibody
    • MAP3K 7 antibody
    • Map3k7 antibody
    • MEKK7 antibody
    • Mitogen activated protein kinase kinase kinase 7 antibody
    • Mitogen-activated protein kinase kinase kinase 7 antibody
    • TAK1 antibody
    • TGF beta activated kinase 1 antibody
    • TGF-beta-activated kinase 1 antibody
    • TGF1a antibody
    • Transforming growth factor beta activated kinase 1 antibody
    • Transforming growth factor-beta-activated kinase 1 antibody
    see all

Anti-TAK1 antibody images

  • ab111096, at 10µg/ml, staining TAK1 in formalin-fixed, paraffin-embedded Human Placenta tissue by Immunohistochemistry.
  • ab111096, at 10µg/ml, staining TAK1 in formalin-fixed, paraffin-embedded Human Prostate tissue by Immunohistochemistry.
  • ab111096, at 10µg/ml, staining TAK1 in formalin-fixed, paraffin-embedded Human Tonsil tissue by Immunohistochemistry.

References for Anti-TAK1 antibody (ab111096)

ab111096 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"