• Product name
  • Description
    Rabbit polyclonal to TAK1
  • Tested applications
    Suitable for: ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to 14 amino acids near the amino terminus of TAK1 isoform (Human)(the amino acid sequence is considered to be commercially sensitive)

  • Positive control
    • Rat thymus cell lysate.



Our Abpromise guarantee covers the use of ab25879 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 67 kDa. The antibody will recognise all 4 isoforms of TAK1. The variation in the MW may also be caused by protein hydrophobicity, migrational speed or post-translational modifications.


  • Function
    Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.
  • Sequence similarities
    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    Association with TAB1/MAP3K7IP1 promotes autophosphorylation and subsequent activation. Association with TAB2/MAP3K7IP2, itself associated with free unanchored Lys-63 polyubiquitin chain, promotes autophosphorylation and subsequent activation of MAP3K7. Dephosphorylation at Thr-187 by PP2A and PPP6C leads to inactivation.
    Ubiquitinated, leading to proteasomal degradation (By similarity). Requires 'Lys-63'-linked polyubiquitination for autophosphorylation and subsequent activation. 'Lys-63'-linked ubiquitination does not lead to proteasomal degradation. Deubiquitinated by CYLD, a protease that selectively cleaves 'Lys-63'-linked ubiquitin chains. Deubiquitinated by Y.enterocolitica YopP.
  • Information by UniProt
  • Database links
  • Alternative names
    • M3K7_HUMAN antibody
    • MAP3K 7 antibody
    • Map3k7 antibody
    • MEKK7 antibody
    • Mitogen activated protein kinase kinase kinase 7 antibody
    • Mitogen-activated protein kinase kinase kinase 7 antibody
    • TAK1 antibody
    • TGF beta activated kinase 1 antibody
    • TGF-beta-activated kinase 1 antibody
    • TGF1a antibody
    • Transforming growth factor beta activated kinase 1 antibody
    • Transforming growth factor-beta-activated kinase 1 antibody
    see all

Anti-TAK1 antibody images

  • Lane 1 : Anti-TAK1 antibody (ab25879) at 1 µg/ml
    Lane 2 : Anti-TAK1 antibody (ab25879) at 2 µg/ml
    Lane 3 : Anti-TAK1 antibody (ab25879) at 4 µg/ml

    Lane 1 : Rat Thymus Tissue Lysate (ab4041)
    Lane 2 : Rat Thymus Tissue Lysate (ab4041)
    Lane 3 : Rat Thymus Tissue Lysate (ab4041)

    Predicted band size : 67 kDa
    Observed band size : 50 kDa (why is the actual band size different from the predicted?)

References for Anti-TAK1 antibody (ab25879)

This product has been referenced in:
  • Liu W  et al. Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers. Clin Cancer Res 13:5028-33 (2007). Read more (PubMed: 17785553) »

See 1 Publication for this product

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