1/100 - 1/1000. Suggested antigen retrieval
using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.
Leukemic stem cell.
Involvement in disease
Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.
Contains 1 basic helix-loop-helix (bHLH) domain.
The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.
Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia. Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells.