Overview

  • Product name
    Tamsulosin hydrochloride
  • Description
    Potent, selective α1A antagonist
  • Biological description
    Potent and selective α1A antagonist (pKi values are 9.97, 8.86 and 9.64 at α1A, α1B and α1D, respectively). Decreases urethral pressure in vivo with a minimal effect on mean arterial blood pressure.
  • Purity
    > 99%

Properties

  • Chemical name
    5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-benzenesulfonamide hydrochloride
  • Molecular weight
    444.97
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C20H28N2O5S.HCl
  • CAS Number
    106463-17-6
  • Storage instructions
    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM and in water to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

    References for Tamsulosin hydrochloride (ab120772)

    This product has been referenced in:
    • Ohtake A  et al. Effects of tamsulosin on resting urethral pressure and arterial blood pressure in anaesthetized female dogs. J Pharm Pharmacol 58:345-50 (2006). Read more (PubMed: 16536901) »
    • Taguchi K  et al. Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes. J Pharmacol Exp Ther 280:1-5 (1997). Read more (PubMed: 8996174) »
    • Takenaka T  et al. [Discovery and development of tamsulosin hydrochloride, a new alpha 1-adrenoceptor antagonist]. Yakugaku Zasshi 115:773-89 (1995). Read more (PubMed: 8531059) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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