Overview

  • Product nameTamsulosin hydrochloride
  • Description
    Potent, selective α1A antagonist
  • Biological descriptionPotent and selective α1A antagonist (pKi values are 9.97, 8.86 and 9.64 at α1A, α1B and α1D, respectively). Decreases urethral pressure in vivo with a minimal effect on mean arterial blood pressure.
  • Purity> 99%

Properties

  • Chemical name5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-benzenesulfonamide hydrochloride
  • Molecular weight444.97
  • Chemical structureChemical Structure
  • Molecular formulaC20H28N2O5S.HCl
  • CAS Number106463-17-6
  • Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in DMSO to 100 mM and in water to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

    References for Tamsulosin hydrochloride (ab120772)

    This product has been referenced in:
    • Ohtake A  et al. Effects of tamsulosin on resting urethral pressure and arterial blood pressure in anaesthetized female dogs. J Pharm Pharmacol 58:345-50 (2006). Read more (PubMed: 16536901) »
    • Taguchi K  et al. Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes. J Pharmacol Exp Ther 280:1-5 (1997). Read more (PubMed: 8996174) »
    • Takenaka T  et al. [Discovery and development of tamsulosin hydrochloride, a new alpha 1-adrenoceptor antagonist]. Yakugaku Zasshi 115:773-89 (1995). Read more (PubMed: 8531059) »

    See 0 Publications for this product

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