Overview

  • Product name
    Anti-TANC1 antibody
  • Description
    Rabbit polyclonal to TANC1
  • Tested applications
    Suitable for: ICC/IF, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: LQEGLQSKGR PVSPQSRAGI GKSLREPVAQ PGLLLQPSKQ AQIVKTSQHL GSGQSAVRNG SMKVQISSQN PPPSPMPGRI AATP, corresponding to amino acids 1491-1574 of Human TANC1.

  • Positive control
    • Human cerebellum tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab122358 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    May be a scaffold component in the postsynaptic density.
  • Sequence similarities
    Belongs to the TANC family.
    Contains 11 ANK repeats.
    Contains 3 TPR repeats.
  • Post-translational
    modifications
    Phosphorylated; probably by MINK1 and TNIK upon stimulation by RAP2A.
  • Cellular localization
    Cell junction > synapse > postsynaptic cell membrane > postsynaptic density.
  • Information by UniProt
  • Database links
  • Alternative names
    • ankyrin repeat and coiled-coil domain-containing protein 1 antibody
    • KIAA1728 antibody
    • Protein TANC1 antibody
    • Rolling pebbles homolog B antibody
    • ROLSB antibody
    • TANC antibody
    • Tanc1 antibody
    • TANC1_HUMAN antibody
    • Tetratricopeptide repeat ankyrin repeat and coiled coil containing 1 antibody
    • Tetratricopeptide repeat ankyrin repeat and coiled coil domain containing protein 1 antibody
    • Tetratricopeptide repeat antibody
    • TPR domain ankyrin repeat and coiled coil containing antibody
    see all

Images

  • Immunofluorescent staining of Human cell line U-2 OS shows positivity in nucleus but not nucleoli and cytoplasm. Recommended concentration of ab122358 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab122358, at 1/35 dilution, staining TANC1 in parffin-embedded Human cerebellum tissue by Immunohistochemistry.

References

ab122358 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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