Overview

  • Product name
  • Description
    Rabbit polyclonal to TANK
  • Tested applications
    Suitable for: WB, ICCmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:- a 14 amino acid peptide from near the amino terminus of human TANK

  • Positive control
    • Daudi Cell Lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab47633 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 47 kDa.
ICC Use a concentration of 2.5 µg/ml.

Target

  • Function
    Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Contains 1 C2H2-type zinc finger.
  • Post-translational
    modifications
    Phosphorylated by IKBKE.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • I TRAF antibody
    • I-TRAF antibody
    • ITRAF antibody
    • Tank antibody
    • TANK_HUMAN antibody
    • TRAF family member associated NF KAPPA B activator antibody
    • TRAF family member associated NFKB activator antibody
    • TRAF family member-associated NF-kappa-B activator antibody
    • TRAF interacting protein antibody
    • TRAF interacting protein TANK isoform a antibody
    • TRAF interacting protein TANK isoform b antibody
    • TRAF-interacting protein antibody
    • TRAF2 antibody
    see all

Images

  • Lane 1 : Anti-TANK antibody (ab47633) at 0.5 µg/ml
    Lane 2 : Anti-TANK antibody (ab47633) at 1 µg/ml

    Lane 1 : Daudi cell lysate at 15 µg per lane.
    Lane 2 : Daudi cell lysate at 15 µg per lane.

    Secondary
    Anti-rabbit IgG HRP at 1:10000

    Predicted band size : 47 kDa
    Observed band size : 52 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 38 kDa. We are unsure as to the identity of these extra bands.
  • ab47633 at 2.5ug/ml staining TANK in Daudi cells by Immunocytochemistry.

References

ab47633 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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