Anti-Tankyrase 2 antibody (ab85690)


  • Product nameAnti-Tankyrase 2 antibody
    See all Tankyrase 2 primary antibodies
  • Description
    Goat polyclonal to Tankyrase 2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Dog
  • Immunogen

    Synthetic peptide with sequence C-


    , from the internal sequence of Human Tankyrase 2, NP_079511.1

  • Positive control
    • Jurkat lysate



Our Abpromise guarantee covers the use of ab85690 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 45, 125 kDa (predicted molecular weight: 127 kDa).


  • FunctionPoly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.
  • Tissue specificityHighly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.
  • Sequence similaritiesContains 15 ANK repeats.
    Contains 1 PARP catalytic domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • Post-translational
    Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation.
    ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.
    The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer.
  • Cellular localizationCytoplasm. Golgi apparatus membrane. Nucleus. Chromosome > telomere. Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.
  • Information by UniProt
  • Database links
  • Alternative names
    • ADP-ribosyltransferase diphtheria toxin-like 6 antibody
    • ARTD6 antibody
    • PARP 5b antibody
    • PARP 5c antibody
    • PARP-5b antibody
    • PARP-5c antibody
    • PARP5B antibody
    • PARP5C antibody
    • pART6 antibody
    • Poly [ADP ribose] polymerase 5B antibody
    • Poly [ADP-ribose] polymerase 5B antibody
    • TANK2 antibody
    • Tankyrase 2 antibody
    • Tankyrase II antibody
    • Tankyrase like protein antibody
    • Tankyrase related protein antibody
    • Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase 2 antibody
    • Tankyrase-2 antibody
    • Tankyrase-like protein antibody
    • Tankyrase-related protein antibody
    • TNKL antibody
    • TNKS 2 antibody
    • TNKS-2 antibody
    • TNKS2 antibody
    • TNKS2_HUMAN antibody
    • TRF1 Interacting Ankyrin Related ADP ribose polymerase 2 antibody
    • TRF1-interacting ankyrin-related ADP-ribose polymerase 2 antibody
    see all

Anti-Tankyrase 2 antibody images

References for Anti-Tankyrase 2 antibody (ab85690)

ab85690 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Sample Xenopus laevis Tissue lysate - whole (embryo)
Loading amount 20 µg
Specification embryo
Gel Running Conditions Reduced Denaturing
Blocking step Milk as blocking agent for 30 minute(s) · Concentration: 5% · Temperature: 20°C

Ms. Sandra Gonzalez

Verified customer

Submitted Nov 27 2012


Expiration date: 26. November 2012

I am very pleased to hear you would like to accept our offer and testab85690 in mouse and/or Xenopus. This code will give youthe value of ab85690 off a futur...

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Thank you for your reply.

I checked the immunogen sequence for ab85690 and have to confirm that most probably this antibody is not only binding to Tankyrase2 but also to Tankyrase1 since the immunogen shows a 90% homology with Tankyrase1. All...

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Thank you very much for your interest in our antibodies.

We expect cross-reactivity from antibodies when the immunogen shows a 85% homology (or higher) with another species.

The homology of theimmunogen with Xenopusis the following:...

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