• Product nameAnti-TAOK2 antibody
    See all TAOK2 primary antibodies
  • Description
    Mouse monoclonal to TAOK2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human TAOK2 aa 831-931.


    Database link: Q9UL54



Our Abpromise guarantee covers the use of ab56571 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionIsoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1, but not isoform 2, activates the JNK MAP kinase pathway through the specific activation of the upstream MKK3 and MKK6 kinases. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of IKKA, and thus NF-kappa-B activation, but not that of JNK. Phosphorylates itself, MBP, activated MAPK8 and tubulins. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization (By similarity). Both isoforms are involved in MAPK14 phosphorylation.
    • Tissue specificityUbiquitously expressed, with a higher level of expression in testis and brain.
    • Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
      Contains 1 protein kinase domain.
    • Post-translational
      Isoforms 1 and 2 are autophosphorylated.
      C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity.
      isoform 2 is phosphorylated at 'Ser-1031' by MAPK14. This phosphorylation is required PCDH8 for endocytosis.
    • Cellular localizationCytoplasmic vesicle membrane. Cytoplasm > cytoskeleton. Nucleus. Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus and Cell projection > dendrite. In dendrites, colocalizes with PCDH8.
    • Information by UniProt
    • Database links
    • Alternative names
      • 1110033K02Rik antibody
      • B230344N16 antibody
      • hKFC C antibody
      • hKFC-C antibody
      • KIAA0881 antibody
      • Kinase from chicken homolog C antibody
      • MAP3K17 antibody
      • mKIAA0881 antibody
      • Prostate derived STE20 like kinase 1 antibody
      • Prostate derived STE20 like kinase PSK antibody
      • Prostate derived sterile 20 like kinase 1 antibody
      • Prostate-derived STE20-like kinase 1 antibody
      • PSK 1 antibody
      • PSK antibody
      • PSK-1 antibody
      • PSK1 antibody
      • PSK1 beta antibody
      • Serine/threonine protein kinase TAO2 antibody
      • Serine/threonine-protein kinase TAO2 antibody
      • TAO 1 antibody
      • TAO 2 antibody
      • TAO kinase 2 antibody
      • TAO1 antibody
      • TAO2 antibody
      • TAOK 2 antibody
      • Taok2 antibody
      • TAOK2_HUMAN antibody
      • Thousand and one amino acid protein 2 antibody
      • Thousand and one amino acid protein kinase antibody
      • UNQ2971/PRO7431 antibody
      see all

    Anti-TAOK2 antibody images

    • Western blot against tagged recombinant protein immunogen using ab56571 TAO antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-TAOK2 antibody (ab56571)

    ab56571 has not yet been referenced specifically in any publications.

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