Overview

  • Product name
  • Description
    Goat polyclonal to TAOK3
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide corresponding to Human TAOK3 aa 396-411.
    Sequence:

    HKKDHVFIRDEAGHGD


    Database link: Q9H2K8

  • Positive control
    • Human Liver lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab21205 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/32000.
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 105 kDa).

Target

  • Function
    Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK.
  • Tissue specificity
    Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.
  • Sequence similarities
    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Cytoplasm. Cell membrane. Also localized to the peripheral cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CTCL tumor antigen HD CL 09 antibody
    • CTCL-associated antigen HD-CL-09 antibody
    • Cutaneous T cell lymphoma tumor antigen HD CL 09 antibody
    • Cutaneous T-cell lymphoma-associated antigen HD-CL-09 antibody
    • Dendritic cell derived protein kinase antibody
    • Dendritic cell-derived protein kinase antibody
    • DKFZp666H245 antibody
    • DPK antibody
    • FLJ31808 antibody
    • hKFC A antibody
    • hKFC-A antibody
    • JIK antibody
    • JNK/SAPK inhibitory kinase antibody
    • JNK/SAPK-inhibitory kinase antibody
    • Jun kinase inhibitory kinase antibody
    • Jun kinase-inhibitory kinase antibody
    • KDS antibody
    • Kinase from chicken homolog A antibody
    • MAP3K18 antibody
    • Serine kinase antibody
    • Serine/threonine-protein kinase TAO3 antibody
    • STE20 like kinase antibody
    • TAO kinase 3 antibody
    • TAOK3 antibody
    • TAOK3_HUMAN antibody
    • Thousand and one amino acid protein 3 antibody
    see all

Images



  • Predicted band size : 105 kDa

    ab21205 (0.1ug/ml) western blot detection of JIK from human liver lysate.

    ab21205 (0.1ug/ml) western blot detection of JIK from human liver lysate.

References

This product has been referenced in:
  • Kapfhamer D  et al. JNK pathway activation is controlled by Tao/TAOK3 to modulate ethanol sensitivity. PLoS One 7:e50594 (2012). WB ; Mouse . Read more (PubMed: 23227189) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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