Overview

  • Product name
  • Description
    Rabbit polyclonal to TAOK3
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human TAOK3 (C terminal) conjugated to keyhole limpet haemocyanin.
    Database link: Q9H2K8

  • Positive control
    • 293 cell lysates transiently transfected with the JIK gene (WB) Human hepatocarcinoma tissue (IHC)

Properties

Applications

Our Abpromise guarantee covers the use of ab62915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Detects a band of approximately 105 kDa (predicted molecular weight: 105 kDa).
ELISA 1/1000.
IHC-P 1/10 - 1/50.

Target

  • Function
    Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK.
  • Tissue specificity
    Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.
  • Sequence similarities
    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Cytoplasm. Cell membrane. Also localized to the peripheral cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CTCL tumor antigen HD CL 09 antibody
    • CTCL-associated antigen HD-CL-09 antibody
    • Cutaneous T cell lymphoma tumor antigen HD CL 09 antibody
    • Cutaneous T-cell lymphoma-associated antigen HD-CL-09 antibody
    • Dendritic cell derived protein kinase antibody
    • Dendritic cell-derived protein kinase antibody
    • DKFZp666H245 antibody
    • DPK antibody
    • FLJ31808 antibody
    • hKFC A antibody
    • hKFC-A antibody
    • JIK antibody
    • JNK/SAPK inhibitory kinase antibody
    • JNK/SAPK-inhibitory kinase antibody
    • Jun kinase inhibitory kinase antibody
    • Jun kinase-inhibitory kinase antibody
    • KDS antibody
    • Kinase from chicken homolog A antibody
    • MAP3K18 antibody
    • Serine kinase antibody
    • Serine/threonine-protein kinase TAO3 antibody
    • STE20 like kinase antibody
    • TAO kinase 3 antibody
    • TAOK3 antibody
    • TAOK3_HUMAN antibody
    • Thousand and one amino acid protein 3 antibody
    see all

Images

  • All lanes : Anti-TAOK3 antibody (ab62915) at 1/50 dilution

    Lane 1 : 293 cell lysates nontransfected
    Lane 2 : 293 cell lysates transiently transfected with the JIK gene

    Lysates/proteins at 2 µg per lane.


    Predicted band size : 105 kDa
    Observed band size : 105 kDa
    Additional bands at : 60 kDa,70 kDa. We are unsure as to the identity of these extra bands.
  • ab62915, at 1/10 dilution, staining TAOK3 in formalin-fixed, paraffin-embedded human hepatocarcinoma tissue by immunohistochemistry. ab62915 was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

References

ab62915 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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