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Rabbit polyclonal to TAP2
Predicted to work with:
Recombinant fragment corresponding to Human TAP2 aa 430-680.
YGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPN RPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL DEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAA AQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLI LDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGK L
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Preservative: 0.02% Sodium azide Constituents: 49% PBS, 50% Glycerol
Concentration information loading...
Immunogen affinity purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/50 - 1/200.
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
1/500 - 1/2000. Predicted molecular weight: 76 kDa.
Use at an assay dependent concentration.
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Involvement in disease
Bare lymphocyte syndrome 1
Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.
The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.
Endoplasmic reticulum membrane. The transmembrane segments seem to form a pore in the membrane.
Information by UniProt
ABC transporter, MHC 2 antibody
Immunocytochemistry/ Immunofluorescence - Anti-TAP2 antibody (ab180611)
Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab180611. Blue DAPI for nuclear staining.
Western blot - Anti-TAP2 antibody (ab180611)
Anti-TAP2 antibody (ab180611) at 1/500 dilution + Human placenta extract
Predicted band size: 76 kDa
has not yet been referenced specifically in any publications.
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