Overview

  • Product nameAnti-TAPA1 antibody [2F7] (Biotin)
    See all TAPA1 primary antibodies
  • Description
    Armenian Hamster monoclonal [2F7] to TAPA1 (Biotin)
  • ConjugationBiotin
  • Tested applicationsSuitable for: Flow Cyt, IHC-Fr, IP, Blockingmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Mouse epithelial cell line PAM212.

  • General notes


    ab25675 can block thymocyte interaction with CD81 in vitro.

Properties

Applications

Our Abpromise guarantee covers the use of ab25675 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 1µg for 106 cells.
IHC-Fr Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
Blocking Use at an assay dependent concentration.

In vitro blocking of thymocyte interactions with CD81.

Target

  • FunctionMay play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May acts a the viral receptor for HCV.
  • Tissue specificityHematolymphoid, neuroectodermal and mesenchymal tumor cell lines.
  • Involvement in diseaseDefects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:613496]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
  • Sequence similaritiesBelongs to the tetraspanin (TM4SF) family.
  • Post-translational
    modifications
    Not glycosylated.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 26 kDa cell surface protein TAPA 1 antibody
    • 26 kDa cell surface protein TAPA-1 antibody
    • 26 kDa cell surface protein TAPA1 antibody
    • CD 81 antibody
    • CD81 antibody
    • CD81 antigen (target of antiproliferative antibody 1) antibody
    • CD81 antigen antibody
    • CD81 molecule antibody
    • CD81_HUMAN antibody
    • CVID6 antibody
    • S5.7 antibody
    • TAPA 1 antibody
    • TAPA1 antibody
    • Target of the antiproliferative antibody 1 antibody
    • Tetraspanin 28 antibody
    • Tetraspanin-28 antibody
    • Tetraspanin28 antibody
    • Tspan 28 antibody
    • Tspan-28 antibody
    • Tspan28 antibody
    see all

References for Anti-TAPA1 antibody [2F7] (Biotin) (ab25675)

This product has been referenced in:

See 1 Publication for this product

Product Wall

Thank you for your inquiry.

How long were the antibodies stored at -20C? We are unsure if freezing will negatively affect the quality of the antibodies since we've never frozen them and then tested them.

I'd recommend to just try ...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"