Anti-TAPA1 antibody [Eat 2] (FITC) (ab23625)

Overview

  • Product name
    Anti-TAPA1 antibody [Eat 2] (FITC)
    See all TAPA1 primary antibodies
  • Description
    Armenian Hamster monoclonal [Eat 2] to TAPA1 (FITC)
  • Conjugation
    FITC. Ex: 493nm, Em: 528nm
  • Specificity
    ab23625 recognises TAPA1 expressed at much higher levels on resting B cells than on T cells, although increased expression on T cells is found following activation.
  • Tested applications
    Suitable for: Flow Cyt, Functional Studiesmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    Tissue/ cell preparation: 38C13, murine B cell line.

  • General notes

    Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC).

Properties

Applications

Our Abpromise guarantee covers the use of ab23625 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 10µl for 106 cells. Induces homotypic aggregation of B cells and inhibits anti Ig and IL4 induced proliferation. It requires the presence of both extracellular loops of TAPA1 for binding.



ab18473-Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.
Functional Studies Use at an assay dependent concentration.

Target

  • Function
    May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May acts a the viral receptor for HCV.
  • Tissue specificity
    Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.
  • Involvement in disease
    Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:613496]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
  • Sequence similarities
    Belongs to the tetraspanin (TM4SF) family.
  • Post-translational
    modifications
    Not glycosylated.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 26 kDa cell surface protein TAPA 1 antibody
    • 26 kDa cell surface protein TAPA-1 antibody
    • 26 kDa cell surface protein TAPA1 antibody
    • CD 81 antibody
    • Cd81 antibody
    • CD81 antigen (target of antiproliferative antibody 1) antibody
    • CD81 antigen antibody
    • CD81 molecule antibody
    • CD81_HUMAN antibody
    • CVID6 antibody
    • S5.7 antibody
    • TAPA 1 antibody
    • TAPA1 antibody
    • Target of the antiproliferative antibody 1 antibody
    • Tetraspanin 28 antibody
    • Tetraspanin-28 antibody
    • Tetraspanin28 antibody
    • Tspan 28 antibody
    • Tspan-28 antibody
    • Tspan28 antibody
    see all

References

ab23625 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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