Overview

  • Product name
  • Description
    Rabbit polyclonal to TARBP1
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    A 17 amino acids synthetic peptide conjugated to KLH, corresponding to a region near the center of Human TARBP1.

  • Positive control
    • Human prostate and Human adrenal tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab115896 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 182 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA.
  • Sequence similarities
    Belongs to the RNA methyltransferase TrmH family.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ30482 antibody
    • Probable methyltransferase TARBP1 antibody
    • TAR (HIV) RNA binding protein 1 antibody
    • TAR antibody
    • TAR RNA loop binding protein antibody
    • TAR RNA-binding protein 1 antibody
    • TAR RNA-binding protein of 185 kDa antibody
    • TARB1_HUMAN antibody
    • TARBP1 antibody
    • TRM3 antibody
    • TRP-185 antibody
    • TRP185 antibody
    see all

Images

  • ab115896, at 5 ug/ml, staining TARBP1 in formalin fixed, paraffin embedded Human Prostate by Immunohistochemistry. Developed using biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • ab115896, at 5 ug/ml, staining TARBP1 in formalin fixed, paraffin embedded Human adrenal by Immunohistochemistry. Developed using biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References

ab115896 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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