Anti-Tau tubulin kinase 2 antibody - N-terminal (ab170799)

Overview

  • Product name
    Anti-Tau tubulin kinase 2 antibody - N-terminal
  • Description
    Rabbit polyclonal to Tau tubulin kinase 2 - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, Flow Cyt, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Tau tubulin kinase 2 aa 224-253 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q6IQ55

  • Positive control
    • K562 cell line lysates. Human lung tissue. K562 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab170799 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 137 kDa.
Flow Cyt 1/10 - 1/50.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

 

IHC-P 1/10 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Serine/threonine kinase which is able to phosphorylate tau on serines.
  • Involvement in disease
    Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11) [MIM:604432]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • KIAA0847 antibody
    • mKIAA0847 antibody
    • SCA11 antibody
    • Spinocerebellar ataxia 11 antibody
    • Tau tubulin kinase 2 antibody
    • Tau-tubulin kinase 2 antibody
    • TTBK antibody
    • TTBK 2 antibody
    • TTBK1 antibody
    • TTBK2 antibody
    • TTBK2_HUMAN antibody
    • TTK antibody
    see all

Images

  • Flow cytometric analysis of K562 cells labeling Tau tubulin kinase 2 using ab170799 at a 1/10 dilution (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used .

  • Immunohistochemical analysis of Formalin/PFA-fixed paraffin-embedded Human lung tissue labeling Tau tubulin kinase 2 with ab170799 at a 1/10 dilution followed by peroxidase conjugation of the secondary antibody and DAB staining.

  • Anti-Tau tubulin kinase 2 antibody - N-terminal (ab170799) at 1/100 dilution + K562 cell line lysates at 35 µg

    Predicted band size: 137 kDa

References

ab170799 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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