Overview

  • Product nameTBB
  • Description
    Selective, cell-permeable casein kinase-2 (CK2) inhibitor
  • Alternative names
    • NSC 231634
  • Biological descriptionSelective, cell-permeable casein kinase-2 (CK2) inhibitor (IC50 = 0.5 μM). Acts in an ATP/GTP competitive manner. Induces apoptosis.
  • Purity> 98%

Properties

    References for TBB (ab120988)

    This product has been referenced in:
    • Duncan JS  et al. An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets. Mol Cell Proteomics 7:1077-88 (2008). Read more (PubMed: 18258654) »
    • Ruzzene M  et al. Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. Biochem J 364:41-7 (2002). Read more (PubMed: 11988074) »
    • Sarno S  et al. Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2'). FEBS Lett 496:44-8 (2001). Read more (PubMed: 11343704) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"