Overview

  • Product nameAnti-TBCD antibody
    See all TBCD primary antibodies
  • Description
    Rabbit polyclonal to TBCD
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to a region within internal sequence amino acids 299-348 (KLVQRLGLTF LKPKVAAWRY QRGCRSLAAN LQLLTQGQSE QKPLILTEDD) of Human TBCD (NM_005993).

  • Positive control
    • HeLa cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab116519 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 133 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionTubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane.
  • Tissue specificityUbiquitously expressed.
  • Sequence similaritiesBelongs to the TBCD family.
    Contains 3 HEAT repeats.
  • Cellular localizationCell junction > tight junction. Lateral cell membrane. Cytoplasm. Cell junction > adherens junction. Localized in cell-cell contacts.
  • Information by UniProt
  • Database links
  • Alternative names
    • Beta tubulin cofactor D antibody
    • Beta-tubulin cofactor D antibody
    • KIAA0988 antibody
    • SSD 1 antibody
    • SSD-1 antibody
    • SSD1 antibody
    • tbcd antibody
    • TBCD_HUMAN antibody
    • tfcD antibody
    • Tubulin folding cofactor D antibody
    • Tubulin specific chaperone D antibody
    • Tubulin-folding cofactor D antibody
    • Tubulin-specific chaperone D antibody
    see all

Anti-TBCD antibody images

  • Anti-TBCD antibody (ab116519) at 1 µg/ml + HeLa cell lysate at 10 µg

    Predicted band size : 133 kDa

References for Anti-TBCD antibody (ab116519)

ab116519 has not yet been referenced specifically in any publications.

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