Overview

  • Product nameAnti-TBCD antibody
    See all TBCD primary antibodies
  • Description
    Mouse polyclonal to TBCD
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human TBCD protein (AAH39654)

  • Positive control
    • TBCD transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab72624 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 75 kDa (predicted molecular weight: 133 kDa).

Target

  • FunctionTubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane.
  • Tissue specificityUbiquitously expressed.
  • Sequence similaritiesBelongs to the TBCD family.
    Contains 3 HEAT repeats.
  • Cellular localizationCell junction > tight junction. Lateral cell membrane. Cytoplasm. Cell junction > adherens junction. Localized in cell-cell contacts.
  • Information by UniProt
  • Database links
  • Alternative names
    • Beta tubulin cofactor D antibody
    • Beta-tubulin cofactor D antibody
    • KIAA0988 antibody
    • SSD 1 antibody
    • SSD-1 antibody
    • SSD1 antibody
    • tbcd antibody
    • TBCD_HUMAN antibody
    • tfcD antibody
    • Tubulin folding cofactor D antibody
    • Tubulin specific chaperone D antibody
    • Tubulin-folding cofactor D antibody
    • Tubulin-specific chaperone D antibody
    see all

Anti-TBCD antibody images

  • All lanes : Anti-TBCD antibody (ab72624) at 1/500 dilution

    Lane 1 : TBCD transfected 293T cell lystae
    Lane 2 : Non transfected 293T cell lystae

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG(H&L)-HRP Conjugate at 1/25000 dilution

    Predicted band size : 133 kDa
    Observed band size : 75 kDa (why is the actual band size different from the predicted?)

References for Anti-TBCD antibody (ab72624)

ab72624 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"