Overview

  • Product name
  • Description
    Rabbit polyclonal to TBLR1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide:

    WPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEW T

    , corresponding to amino acids 200-250 of Human TBLR1.

  • Positive control
    • Tested with human brain cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab13799 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: Use at a concentration of 1-3 µg/ml. Detects a band of approximately 61 and 54 kDa (predicted molecular weight: 76 kDa).

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
    • Tissue specificity
      Ubiquitous.
    • Sequence similarities
      Belongs to the WD repeat EBI family.
      Contains 1 F-box-like domain.
      Contains 1 LisH domain.
      Contains 8 WD repeats.
    • Domain
      The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • C21 antibody
      • DC42 antibody
      • F box like/WD repeat containing protein TBL1XR1 antibody
      • F-box-like/WD repeat-containing protein TBL1XR1 antibody
      • FLJ12894 antibody
      • IRA1 antibody
      • Nuclear receptor corepressor/HDAC3 complex subunit antibody
      • Nuclear receptor corepressor/HDAC3 complex subunit TBLR1 antibody
      • TBL1 related protein 1 antibody
      • TBL1-related protein 1 antibody
      • TBL1R_HUMAN antibody
      • TBL1XR1 antibody
      • Transducin (beta) like 1 X linked receptor 1 antibody
      • Transducin beta like 1X related protein 1 antibody
      • Transducin beta-like 1X-related protein 1 antibody
      see all

    Images

    • Western blot analysis of the two forms of TBLR1 in 20 µgs of human brain cell lysate using ab13799 at 1 µg/ml.

    References

    This product has been referenced in:
    • Ebert DH  et al. Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR. Nature 499:341-5 (2013). Read more (PubMed: 23770587) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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