Anti-TBLR1/TBL1XR1 antibody (ab24550)
Key features and details
- Rabbit polyclonal to TBLR1/TBL1XR1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-TBLR1/TBL1XR1 antibody
See all TBLR1/TBL1XR1 primary antibodies -
Description
Rabbit polyclonal to TBLR1/TBL1XR1 -
Host species
Rabbit -
Specificity
Does not cross-react with TBL1. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein corresponding to Human TBLR1/TBL1XR1.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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ChIP Related Products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab24550 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/2000. Detects a band of approximately 64 kDa (predicted molecular weight: 56 kDa).
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Notes |
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WB
1/2000. Detects a band of approximately 64 kDa (predicted molecular weight: 56 kDa). |
Target
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Function
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. -
Tissue specificity
Ubiquitous. -
Sequence similarities
Belongs to the WD repeat EBI family.
Contains 1 F-box-like domain.
Contains 1 LisH domain.
Contains 8 WD repeats. -
Domain
The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes. -
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 79718 Human
- Omim: 608628 Human
- SwissProt: Q9BZK7 Human
- Unigene: 581171 Human
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Alternative names
- C21 antibody
- DC42 antibody
- F box like/WD repeat containing protein TBL1XR1 antibody
see all
Images
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Anti-TBLR1/TBL1XR1 antibody (ab24550) at 1/2000 dilution + HeLa nuclear extract
Predicted band size: 56 kDa
Observed band size: 60 kDa why is the actual band size different from the predicted?
Protocols
Datasheets and documents
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Datasheet download
References (11)
ab24550 has been referenced in 11 publications.
- Yang H et al. GINS1 promotes the proliferation and migration of glioma cells through USP15-mediated deubiquitination of TOP2A. iScience 25:104952 (2022). PubMed: 36065190
- Wu C et al. Long Noncoding RNA Plasmacytoma Variant Translocation 1 Regulates Cisplatin Resistance via miR-3619-5p/TBL1XR1 Axis in Gastric Cancer. Cancer Biother Radiopharm N/A:N/A (2020). PubMed: 32407172
- Moretti C et al. Battle of the Sex Chromosomes: Competition between X and Y Chromosome-Encoded Proteins for Partner Interaction and Chromatin Occupancy Drives Multicopy Gene Expression and Evolution in Muroid Rodents. Mol Biol Evol 37:3453-3468 (2020). PubMed: 32658962
- Zhao Y et al. TBL1XR1 as a potential therapeutic target that promotes epithelial-mesenchymal transition in lung squamous cell carcinoma. Exp Ther Med 17:91-98 (2019). PubMed: 30651768
- Moretti C et al. SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation. Cell Death Differ 24:1029-1044 (2017). WB, IP ; Mouse . PubMed: 28475176