Overview

  • Product nameAnti-TBLR1 antibody
    See all TBLR1 primary antibodies
  • Description
    Rabbit polyclonal to TBLR1
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region between residue 100 and 150 of Human TBLR1 (Swiss-Prot Q9BZK7).

  • Positive control
    • Human prostate adenocarcinoma; human breast adenocarcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab84141 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionF-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
    • Tissue specificityUbiquitous.
    • Sequence similaritiesBelongs to the WD repeat EBI family.
      Contains 1 F-box-like domain.
      Contains 1 LisH domain.
      Contains 8 WD repeats.
    • DomainThe F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • C21 antibody
      • DC42 antibody
      • F box like/WD repeat containing protein TBL1XR1 antibody
      • F-box-like/WD repeat-containing protein TBL1XR1 antibody
      • FLJ12894 antibody
      • IRA1 antibody
      • Nuclear receptor corepressor/HDAC3 complex subunit antibody
      • Nuclear receptor corepressor/HDAC3 complex subunit TBLR1 antibody
      • TBL1 related protein 1 antibody
      • TBL1-related protein 1 antibody
      • TBL1R_HUMAN antibody
      • TBL1XR1 antibody
      • Transducin (beta) like 1 X linked receptor 1 antibody
      • Transducin beta like 1X related protein 1 antibody
      • Transducin beta-like 1X-related protein 1 antibody
      see all

    Anti-TBLR1 antibody images

    • ab84141, at 1/250 dilution, staining TBLR1 in formalin-fixed, paraffin-embedded human prostate adenocarcinoma by Immunohistochemistry using DAB staining.
    • ab84141, at 1/250 dilution, staining TBLR1 in formalin-fixed, paraffin-embedded human breast adenocarcinoma by Immunohistochemistry using DAB staining.

    References for Anti-TBLR1 antibody (ab84141)

    ab84141 has not yet been referenced specifically in any publications.

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