Overview

  • Product name
  • Description
    Rabbit polyclonal to TBLR1
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Monkey, Zebrafish
  • Immunogen

    Recombinant fragment containing a sequence corresponding to a region within amino acids 210-484 of Human TBLR1 (NP_078941).

  • Positive control
    • A431 whole cell lysate; Cal27 xenograft; HeLa cells; 293T, H1299, Molt-4 and Raji cell lines

Properties

Applications

Our Abpromise guarantee covers the use of ab97398 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 56 kDa.
IHC-P 1/100 - 1/250.
ICC/IF 1/100 - 1/200.

Target

  • Function
    F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Belongs to the WD repeat EBI family.
    Contains 1 F-box-like domain.
    Contains 1 LisH domain.
    Contains 8 WD repeats.
  • Domain
    The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • C21 antibody
    • DC42 antibody
    • F box like/WD repeat containing protein TBL1XR1 antibody
    • F-box-like/WD repeat-containing protein TBL1XR1 antibody
    • FLJ12894 antibody
    • IRA1 antibody
    • Nuclear receptor corepressor/HDAC3 complex subunit antibody
    • Nuclear receptor corepressor/HDAC3 complex subunit TBLR1 antibody
    • TBL1 related protein 1 antibody
    • TBL1-related protein 1 antibody
    • TBL1R_HUMAN antibody
    • TBL1XR1 antibody
    • Transducin (beta) like 1 X linked receptor 1 antibody
    • Transducin beta like 1X related protein 1 antibody
    • Transducin beta-like 1X-related protein 1 antibody
    see all

Images

  • Anti-TBLR1 antibody (ab97398) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 56 kDa
  • ab97398, at 1/100 dilution, staining TBLR1 in paraffin-embedded Cal27 xenograft by Immunohistochemistry.
  • Immunofluorescence analysis of TBLR1 in paraformaldehyde-fixed HeLa cells, using ab97398 at 1/200 dilution (top image) and merged with DNA probe (bottom image).

References

ab97398 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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