Anti-TBX1 antibody [EPR3289(2)] (ab109313)

Overview

  • Product nameAnti-TBX1 antibody [EPR3289(2)]
    See all TBX1 primary antibodies
  • Description
    Rabbit monoclonal [EPR3289(2)] to TBX1
  • Tested applicationsSuitable for: WB, IPmore details
    Unsuitable for: Flow Cyt,ICC or IHC-P
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive)

  • Positive control
    • PC12, F9, Neuro-2a, Jurkat and NCCIT cell lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Properties

Applications

Our Abpromise guarantee covers the use of ab109313 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 43 kDa (predicted molecular weight: 43 kDa).
IP 1/10 - 1/100.
  • Application notesIs unsuitable for Flow Cyt,ICC or IHC-P.
  • Target

    • FunctionProbable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries.
    • Involvement in diseaseHaploinsufficiency of the TBX1 gene is responsible for most of the physical malformations present in DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS) [MIM:188400, 192430]. DGS is characterized by the association of several malformations: hypoplastic thymus and parathyroid glands, congenital conotruncal cardiopathy, and a subtle but characteristic facial dysmorphology. VCFS is marked by the association of congenital conotruncal heart defects, cleft palate or velar insufficiency, facial dysmorpholgy and learning difficulties. It is now accepted that these two syndromes represent two forms of clinical expression of the same entity manifesting at different stages of life.
      Defects in TBX1 are a cause of DiGeorge syndrome (DGS) [MIM:188400].
      Defects in TBX1 are a cause of velocardiofacial syndrome (VCFS) [MIM:192430].
      Defects in TBX1 are a cause of conotruncal heart malformations (CTHM) [MIM:217095]. CTHM consist of cardiac outflow tract defects, such as tetralogy of Fallot, pulmonary atresia, double-outlet right ventricle, truncus arteriosus communis, and aortic arch anomalies.
    • Sequence similaritiesContains 1 T-box DNA-binding domain.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Brachyury antibody
      • CAFS antibody
      • CTHM antibody
      • DGCR antibody
      • DGS antibody
      • DORV antibody
      • T box antibody
      • T box 1 antibody
      • T box 1 transcription factor antibody
      • T box 1 transcription factor C antibody
      • T box protein 1 antibody
      • T box transcription factor TBX 1 antibody
      • T box transcription factor TBX1 antibody
      • T-box protein 1 antibody
      • T-box transcription factor TBX1 antibody
      • TBX 1 antibody
      • TBX 1C antibody
      • tbx1 antibody
      • TBX1_HUMAN antibody
      • TBX1C antibody
      • Testis specific T box protein antibody
      • Testis-specific T-box protein antibody
      • TGA antibody
      • VCFS antibody
      see all

    Anti-TBX1 antibody [EPR3289(2)] images

    • All lanes : Anti-TBX1 antibody [EPR3289(2)] (ab109313) at 1/1000 dilution

      Lane 1 : PC12 lysate
      Lane 2 : F9 lysate
      Lane 3 : Neuro-2a lysate
      Lane 4 : Jurkat lysate
      Lane 5 : NCCIT lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 43 kDa
      Observed band size : 43 kDa

    References for Anti-TBX1 antibody [EPR3289(2)] (ab109313)

    ab109313 has not yet been referenced specifically in any publications.

    Product Wall

    This antibody recognizes an epitope within AA 90-120.

    Thank you for contacting me and for keeping me updated about the results with the Tbx1 and Twist antibodies. I'm sorry to hear that the results are not good at this point, but please let me know if there is anything I can do to help in that situation. ...

    Read More

    Thank you for your call today. Please see below for your testing codes, and let me know if you have any questions or need anything else from me.

    DISCOUNT CODES:
    Ab109313: ***
    Ab49254: ***

    Expiration date: August 28, 2012. <...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"