The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 79 kDa.
FunctionTranscriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation.
Tissue specificityWidely expressed.
Involvement in diseaseDefects in TBX3 are the cause of ulnar-mammary syndrome (UMS) [MIM:181450]. UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands.