Overview

  • Product nameAnti-TCCR antibody [MM0563-8A5]
    See all TCCR primary antibodies
  • Description
    Mouse monoclonal [MM0563-8A5] to TCCR
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human recombinant TCCR extracellular domain

  • General notesReconstituted antibody should be aliquoted and can be stored frozen at < -20°C for at least six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Properties

Applications

Our Abpromise guarantee covers the use of ab89745 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 69 kDa.

Target

  • FunctionReceptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
  • Tissue specificityHighly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes.
  • Sequence similaritiesBelongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 3 fibronectin type-III domains.
  • DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Class I cytokine receptor antibody
    • CRL1 antibody
    • Cytokine receptor-like 1 antibody
    • I27RA_HUMAN antibody
    • IL-27 receptor subunit alpha antibody
    • IL-27R subunit alpha antibody
    • IL-27R-alpha antibody
    • IL-27RA antibody
    • IL27R alpha antibody
    • IL27R antibody
    • Il27ra antibody
    • Interleukin 27 receptor alpha chain precursor antibody
    • Interleukin 27 receptor antibody
    • Interleukin-27 receptor subunit alpha antibody
    • Protein CRL1 antibody
    • T cell cytokine receptor type 1 antibody
    • TCCR antibody
    • Type 1 T cell cytokine receptor antibody
    • Type I T-cell cytokine receptor antibody
    • WSX-1 antibody
    • WSX1 antibody
    • ZcytoR1 antibody
    see all

References for Anti-TCCR antibody [MM0563-8A5] (ab89745)

ab89745 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"