Overview

  • Product name
  • Description
    Rabbit polyclonal to TCEB1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 68-98 of Human TCEB1 (Accession: NP_005639.1).

  • Positive control
    • Jurkat cell line lysates.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab123730 was purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab123730 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 12 kDa.

Target

  • Function
    SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
    The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
  • Tissue specificity
    Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3.
  • Sequence similarities
    Belongs to the SKP1 family.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Elo C antibody
    • EloC antibody
    • ELOC_HUMAN antibody
    • Elongin 15 kDa subunit antibody
    • Elongin C antibody
    • Elongin-C antibody
    • ElonginC antibody
    • RNA polymerase II transcription factor SIII subunit C antibody
    • SIII antibody
    • SIII p15 antibody
    • TCEB 1 antibody
    • tceb1 antibody
    • Transcription elongation factor B (SIII) polypeptide 1 antibody
    • Transcription elongation factor B polypeptide 1 antibody
    see all

Images

  • Anti-TCEB1 antibody (ab123730) at 1/100 dilution + Jurkat cell line lysates at 35 µg

    Predicted band size : 12 kDa

References

ab123730 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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