Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab58270 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionHeterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer.
    • Involvement in diseaseNote=Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1; Translocation t(17;19)(q22;p13.3) with HLF. Inversion inv(19)(p13;q13) with TFPT.
    • Sequence similaritiesContains 1 basic helix-loop-helix (bHLH) domain.
    • Domainthe 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
    • Post-translational
      modifications
      Phosphorylated following NGF stimulation.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • AGM8 antibody
      • bHLHb21 antibody
      • Class B basic helix-loop-helix protein 21 antibody
      • E12 antibody
      • E2A antibody
      • E2A immunoglobulin enhancer binding factors E12/E47 antibody
      • E47 antibody
      • Helix loop helix protein HE47 antibody
      • Immunoglobulin enhancer-binding factor E12/E47 antibody
      • Immunoglobulin transcription factor 1 antibody
      • ITF1 antibody
      • Kappa-E2-binding factor antibody
      • MGC129647 antibody
      • MGC129648 antibody
      • Negative vitamin D response element binding protein antibody
      • NOL1-TCF3 fusion antibody
      • TCF-3 antibody
      • Tcf3 antibody
      • TFE2_HUMAN antibody
      • transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) antibody
      • Transcription factor 3 antibody
      • transcription factor 3 variant 3 antibody
      • Transcription factor E2-alpha antibody
      • Transcription factor ITF-1 antibody
      • VDIR antibody
      • VDR interacting repressor antibody
      • vitamin D receptor-interacting repressor antibody
      see all

    Anti-TCF3 / E2A antibody images



    • Predicted band size : 68 kDa
      TCF3 / E2A antibody (ab58270) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References for Anti-TCF3 / E2A antibody (ab58270)

    ab58270 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"