Overview

  • Product nameAnti-TCF7 antibody - N-terminal
    See all TCF7 primary antibodies
  • Description
    Rabbit polyclonal to TCF7 - N-terminal
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide from the N-terminal region of human TCF7 conjugated to KLH

  • Positive control
    • Mouse heart tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab71251 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).

Target

  • FunctionTranscriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
  • Tissue specificityPredominantly in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.
  • Sequence similaritiesBelongs to the TCF/LEF family.
    Contains 1 HMG box DNA-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ36364 antibody
    • MGC47735 antibody
    • OTTHUMP00000159391 antibody
    • T cell factor 1 antibody
    • T cell specific transcription factor 1 antibody
    • T-cell factor 1 antibody
    • T-cell-specific transcription factor 1 antibody
    • TCF-1 antibody
    • TCF-7 antibody
    • TCF1 antibody
    • Tcf7 antibody
    • TCF7 transcription factor 7 antibody
    • TCF7_HUMAN antibody
    • Transcription factor 7 (T cell specific HMG box) antibody
    • Transcription factor 7 antibody
    • Transcription factor-7, T-cell specific antibody
    • Transcription factor-7, T-cell specific, 1 antibody
    see all

Anti-TCF7 antibody - N-terminal images

  • Anti-TCF7 antibody - N-terminal (ab71251) at 1/60 dilution + mouse heart tissue lysate at 35 µg

    Predicted band size : 42 kDa
    Observed band size : 42 kDa

References for Anti-TCF7 antibody - N-terminal (ab71251)

ab71251 has not yet been referenced specifically in any publications.

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