Overview

  • Product nameAnti-TCIRG1 antibody
    See all TCIRG1 primary antibodies
  • Description
    Mouse monoclonal to TCIRG1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment: QLHQLQLHAA VLRQGHEPQL AAAHTDGASE RTPLLQAPGG PHQDLRVNFV AGAVEPHKAP ALERLLWRAC RGFLIASFRE LEQPLEHPVT GEPATWMTFL , corresponding to amino acids 121-221 of Human TCIRG1

Properties

Applications

Our Abpromise guarantee covers the use of ab56607 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPart of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation.
    • Tissue specificityIsoform long is highly expressed in osteoclastomas. Isoform short is highly expressed in thymus.
    • Involvement in diseaseDefects in TCIRG1 are the cause of osteopetrosis autosomal recessive type 1 (OPTB1) [MIM:259700]; also called autosomal recessive Albers-Schonberg disease or infantile malignant osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. The features of OPTB1 are macrocephaly, progressive deafness and blindness, hepatosplenomegaly, and severe anemia beginning in early infancy or in fetal life. Deafness and blindness are generally thought to represent effects of pressure on nerves.
    • Sequence similaritiesBelongs to the V-ATPase 116 kDa subunit family.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • a3 antibody
      • Atp 6i antibody
      • Atp6i antibody
      • ATP6N1C antibody
      • ATP6V0A3 antibody
      • ATPase H+ transporting 116kD antibody
      • OC 116 antibody
      • OC 116 kDa antibody
      • OC 116kDa antibody
      • OC-116 kDa antibody
      • OC116 antibody
      • OPTB 1 antibody
      • OPTB1 antibody
      • Osteoclastic proton pump 116 kDa subunit antibody
      • Specific 116 kDa vacuolar proton pump subunit antibody
      • Stv 1 antibody
      • Stv1 antibody
      • T cell immune regulator 1 antibody
      • T cell immune regulator 1 ATPase H+ transporting lysosomal V0 subunit A antibody
      • T cell immune regulator 1 ATPase H+ transporting lysosomal V0 subunit A3 antibody
      • T cell immune response cDNA 7 antibody
      • T cell immune response cDNA7 protein antibody
      • T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a antibody
      • T-cell immune regulator 1 antibody
      • T-cell immune response cDNA7 protein antibody
      • TCIRG 1 antibody
      • TCIRG1 antibody
      • TIRC 7 antibody
      • TIRC7 antibody
      • V ATPase 116 kDa antibody
      • V ATPase 116 kDa isoform a3 antibody
      • V type proton ATPase 116 kDa subunit a antibody
      • V-ATPase 116 kDa isoform a3 antibody
      • V-type proton ATPase 116 kDa subunit a isoform 3 antibody
      • Vacuolar proton translocating ATPase 116 kDa subunit A antibody
      • Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3 antibody
      • Vph 1 antibody
      • Vph1 antibody
      • VPP3_HUMAN antibody
      see all

    Anti-TCIRG1 antibody images

    • Western blot against tagged recombinant protein immunogen using ab56607 TCIRG1 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-TCIRG1 antibody (ab56607)

    ab56607 has not yet been referenced specifically in any publications.

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    Thank you for contacting us and for your interest in our products. As far as we are aware, ab56607 has never been tested with samples from mouse. All tested species cross-reactivity information is stated on our datasheets, and these are updated as ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"