Overview

  • Product nameAnti-Tcl1 antibody
    See all Tcl1 primary antibodies
  • Description
    Goat polyclonal to Tcl1
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Macaque Monkey
  • Immunogen

    Synthetic peptide:

    QLYPDGRYRSSD

    , corresponding to internal sequence amino acids 77-88 of Human Tcl1

  • Positive control
    • Daudi and Jurkat cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab65939 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesWB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 16 kDa (predicted molecular weight: 13 kDa).
    Peptide ELISA: antibody detection limit dilution 1:32,000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionEnhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
    • Tissue specificityRestricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
    • Involvement in diseaseNote=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
    • Sequence similaritiesBelongs to the TCL1 family.
    • Cellular localizationCytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Microsomal fraction.
    • Information by UniProt
    • Database links
    • Alternative names
      • Anti TCL1A antibody
      • Lymphoma/leukemia, T-cell antibody
      • Oncogene TCL-1 antibody
      • Oncogene TCL1 antibody
      • P14 TCL1 antibody
      • P14 TCL1 protein antibody
      • Protein p14 TCL1 antibody
      • T cell leukemia 1 antibody
      • T cell lymphoma 1 antibody
      • T cell lymphoma 1A antibody
      • T-cell leukemia/lymphoma protein 1A antibody
      • TCL 1 protein antibody
      • TCL1 antibody
      • TCL1 oncogene antibody
      • TCL1 PEN antibody
      • Tcl1a antibody
      • TCL1A antibody antibody
      • TCL1A_HUMAN antibody
      see all

    Anti-Tcl1 antibody images

    References for Anti-Tcl1 antibody (ab65939)

    ab65939 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"