Overview

  • Product nameAnti-Tcl1 antibody
    See all Tcl1 primary antibodies
  • Description
    Mouse polyclonal to Tcl1
  • Tested applicationsSuitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human Tcl1 protein (AAH14024.1).

  • Positive control
    • Human spleen tissue lysate, Tcl1 transfected 293T cell line, HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab88602 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 13 kDa.
ICC/IF Use a concentration of 10 µg/ml.

Target

  • FunctionEnhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
  • Tissue specificityRestricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
  • Involvement in diseaseNote=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
  • Sequence similaritiesBelongs to the TCL1 family.
  • Cellular localizationCytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Microsomal fraction.
  • Information by UniProt
  • Database links
  • Alternative names
    • Anti TCL1A antibody
    • Lymphoma/leukemia, T-cell antibody
    • Oncogene TCL-1 antibody
    • Oncogene TCL1 antibody
    • P14 TCL1 antibody
    • P14 TCL1 protein antibody
    • Protein p14 TCL1 antibody
    • T cell leukemia 1 antibody
    • T cell lymphoma 1 antibody
    • T cell lymphoma 1A antibody
    • T-cell leukemia/lymphoma protein 1A antibody
    • TCL 1 protein antibody
    • TCL1 antibody
    • TCL1 oncogene antibody
    • TCL1 PEN antibody
    • Tcl1a antibody
    • TCL1A antibody antibody
    • TCL1A_HUMAN antibody
    see all

Anti-Tcl1 antibody images

  • Anti-Tcl1 antibody (ab88602) at 1 µg/ml + Human spleen tissue lysate at 50 µg
    Developed using the ECL technique

    Predicted band size : 13 kDa
    Observed band size : 13 kDa
  • All lanes : Anti-Tcl1 antibody (ab88602) at 1 µg/ml

    Lane 1 : cell lysate from Tcl1 transfected 293T cells
    Lane 2 : cell lysate from non transfected 293T cells

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 13 kDa
    Observed band size : ~13 kDa (why is the actual band size different from the predicted?)
  • ab88602 at 10 µg/ml detecting Tcl1 in paraformaldehyde fixed, permeabilised HeLa cells by immunofluorescence.

References for Anti-Tcl1 antibody (ab88602)

ab88602 has not yet been referenced specifically in any publications.

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