Anti-TCR alpha + beta + epithelial tumor antibody [R73 + CC52] (ab5178)

Overview

  • Product name
    Anti-TCR alpha + beta + epithelial tumor antibody [R73 + CC52]
  • Description
    Mouse monoclonal [R73 + CC52] to TCR alpha + beta + epithelial tumor
  • Host species
    Mouse
  • Specificity
    Quadroma clones producing functional bispecific antibodies were selected by testing the ability of the quadroma products to induce T cells to lyse the appropriate tumor cells.
  • Tested applications
    Suitable for: Cellular Activationmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    This bi-specific antibody was generated by fusion of the R73 producing hybridoma with the CC52 producing hybridoma: R73 = Rat T Blasts and erythrocytes. CC52 = Rat colonic adenocarcinoma cells (CC531)

  • General notes

    Please note that this antibody is an oligoclonal antibody. It is a cocktail of monoclonal antibodies that have been carefully selected. Oligoclonal antibodies have not only the specificity and batch-to-batch consistency of a monoclonal antibody, but also have the advantage of the sensitivity of a polyclonal antibody due to their ability to recognize multiple epitopes on an antigen. This cocktail sonsists of anti-rat T cell receptor alpha + beta  antibody (clone R73) and anti-epithelial tumor antibody (clone CC52).

Properties

Applications

Our Abpromise guarantee covers the use of ab5178 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Cellular Activation Use at an assay dependent dilution.

Target

References

This product has been referenced in:
  • Beun GD  et al. T-cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model: III. Activation of resting T cells and tumor neutralization induced by bispecific antibodies. J Immunother 13:223-31 (1993). Read more (PubMed: 8334106) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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