Anti-TCR gamma + TCR delta antibody [UC7-13D5] (ab25252)

Overview

  • Product name
    Anti-TCR gamma + TCR delta antibody [UC7-13D5]
    See all TCR gamma + TCR delta primary antibodies
  • Description
    Armenian Hamster monoclonal [UC7-13D5] to TCR gamma + TCR delta
  • Specificity
    This antibody does not react with alpha-beta TCR expressing cells.
  • Tested applications
    Suitable for: Flow Cyt, IPmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    The details of the immunogen for this antibody are not available.

  • General notes


    This antibody has been shown to be useful in studies of in vitro activation of gamma-delta TCR bearing cells and in vitro depletion of gamma-delta TCR expressing cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab25252 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 3µg for 106 cells. ab18479-Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.

Target

  • Relevance
    T cell receptors (TCR) recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one a and one b chain or one d and one g chain. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. The g/d TCR associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most g/d T cells are CD4-/CD8-, some are CD8+. T cells expressing the g/d TCR have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease.
  • Cellular localization
    Type I membrane protein
  • Database links
  • Alternative names
    • CD_antigen=CD3d antibody
    • CD3D antibody
    • CD3G antibody
    • T cell antigen receptor delta polypeptide antibody
    • T cell antigen receptor gamma polypeptide antibody
    • T cell rearranging gene gamma antibody
    • T cell receptor delta antibody
    • T cell receptor delta locus antibody
    • T cell receptor gamma antibody
    • T cell receptor gamma chain C region PT gamma 1/2 antibody
    • T cell receptor gamma cluster antibody
    • T cell receptor gamma locus antibody
    • T cell receptor T3 delta chain antibody
    • T cell receptor, delta (V,D,J,C) antibody
    • T cell receptors antibody
    • T cell surface glycoprotein CD3 delta chain antibody
    • T-cell receptor T3 gamma chain antibody
    • T-cell surface glycoprotein CD3 gamma chain antibody
    • T3D antibody
    • T3G antibody
    • TCRD antibody
    • TCRDV1 antibody
    • TCRG antibody
    • TRD antibody
    • TRD locus antibody
    • TRD@ antibody
    • TRG antibody
    • TRG locus antibody
    • TRGC2 antibody
    see all

References for Anti-TCR gamma + TCR delta antibody [UC7-13D5] (ab25252)

ab25252 has not yet been referenced specifically in any publications.

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We do not perform epitope mapping in-house, however the below reference article states that this clone recognizes all murine TCR gamma and deltaheterodimers.

Bluestone, J.A., et al. 1991. Immunol. Rev. 1...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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