Selective JNK2/3 inhibitor (pIC50 values are <5.6, 6.5 and 6.7 for JNK1, JNK2 and JNK3, respectively). No selectivity for 30 other kinases including p38 (pIC50 = <4.8), ERK2, Alk5, c-Fms, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, Tie-2 and VegFr2 (pIC50 = <5).
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.