Overview

  • Product nameAnti-TDP1 antibody
    See all TDP1 primary antibodies
  • Description
    Rabbit polyclonal to TDP1
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region between residues 1 and 50 of human TDP1 (NP_001008744.1)

  • Positive control
    • Human Anaplastic Thyroid Carcinoma, Breast Carcinoma, Ovarian Carcinoma, Pancreatic Islet Cell Tumor, Prostate Carcinoma and Stomach Adenocarcinoma tissues.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab84747 was affinity purified using an epitope specific to TDP1 immobilized on solid support.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab84747 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 - 1/500.
    Epitope exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionDNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
    • Tissue specificityUbiquitously expressed. Similar expression throughout the central nervous system (whole brain, amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased expression in testis and thymus.
    • Involvement in diseaseSpinocerebellar ataxia, autosomal recessive, with axonal neuropathy
    • Sequence similaritiesBelongs to the tyrosyl-DNA phosphodiesterase family.
    • Post-translational
      modifications
      Phosphorylated on serine and/or threonine residues, but not on tyrosine residues.
    • Cellular localizationNucleus. Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • AI838772 antibody
      • AW493413 antibody
      • FLJ11090 antibody
      • MGC104252 antibody
      • MGC112732 antibody
      • RP24-311F12.2 antibody
      • SCAN1 antibody
      • TDP1 antibody
      • TYDP antibody
      • TYDP1_HUMAN antibody
      • Tyr-DNA phosphodiesterase 1 antibody
      • Tyrosyl-DNA phosphodiesterase 1 antibody
      see all

    Anti-TDP1 antibody images

    • ab84747 at 1/250 dilution staining TDP1 in human ovarian tumor by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.
    • ab84747 at 1/250 dilution staining TDP1 in human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

    References for Anti-TDP1 antibody (ab84747)

    ab84747 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"