Overview

  • Product name
  • Description
    Mouse polyclonal to TDRD3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Cow, Chimpanzee, Cynomolgus monkey, Rhesus monkey
  • Immunogen

    Full length protein, corresponding to amino acids 1-651 of Human TDRD3 (NP_110421.1).

  • Positive control
    • TDRD3 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab169059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 73 kDa.

Target

  • Function
    Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
  • Tissue specificity
    Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • Sequence similarities
    Contains 1 Tudor domain.
    Contains 1 UBA domain.
  • Domain
    The Tudor domain specifically recognizes and binds asymmetric dimethylation of histone H3 'Arg-17' (H3R17me2a) and histones H4 'Arg-3', 2 tags for epigenetic transcriptional activation.
  • Cellular localization
    Cytoplasm. Nucleus. Predominantly cytoplasmic. Associated with actively translating polyribosomes and with mRNA stress granules.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4732418C03Rik antibody
    • 6720468N18 antibody
    • FLJ21007 antibody
    • OTTHUMP00000018485 antibody
    • TDRD 3 antibody
    • tdrd3 antibody
    • TDRD3_HUMAN antibody
    • Tudor domain containing 3 antibody
    • Tudor domain containing protein 3 antibody
    • Tudor domain-containing protein 3 antibody
    see all

Images

  • All lanes : Anti-TDRD3 antibody (ab169059) at 1 µg/ml

    Lane 1 : TDRD3 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution
    Developed using the ECL technique

    Predicted band size : 73 kDa

References

ab169059 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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