Overview

  • Product name
  • Description
    Rabbit polyclonal to TDRD3
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Gorilla, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region between residues 400 and 450 of Human TDRD3 (NP_110421.1)

  • Positive control
    • HeLa whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab95878 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-5 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
    • Tissue specificity
      Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
    • Sequence similarities
      Contains 1 Tudor domain.
      Contains 1 UBA domain.
    • Domain
      The Tudor domain specifically recognizes and binds asymmetric dimethylation of histone H3 'Arg-17' (H3R17me2a) and histones H4 'Arg-3', 2 tags for epigenetic transcriptional activation.
    • Cellular localization
      Cytoplasm. Nucleus. Predominantly cytoplasmic. Associated with actively translating polyribosomes and with mRNA stress granules.
    • Information by UniProt
    • Database links
    • Alternative names
      • 4732418C03Rik antibody
      • 6720468N18 antibody
      • FLJ21007 antibody
      • OTTHUMP00000018485 antibody
      • TDRD 3 antibody
      • tdrd3 antibody
      • TDRD3_HUMAN antibody
      • Tudor domain containing 3 antibody
      • Tudor domain containing protein 3 antibody
      • Tudor domain-containing protein 3 antibody
      see all

    References

    ab95878 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab95878.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    Sign up