Anti-TEA domain family member 2 antibody (ab92279)

Overview

  • Product name
    Anti-TEA domain family member 2 antibody
    See all TEA domain family member 2 primary antibodies
  • Description
    Goat polyclonal to TEA domain family member 2
  • Host species
    Goat
  • Specificity
    Not expected to cross-react with other TEA domain family proteins.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog
  • Immunogen

    Synthetic peptide:

    C-EPPDAVDSYQRH

    , corresponding to internal amino acids 238 - 249 of Human TEA domain family member 2 (NP_003589.1).

  • Positive control
    • Human ileum tissue lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Purified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab92279 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 49 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
    • Sequence similarities
      Contains 1 TEA DNA-binding domain.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Embryonic TEA domain containing factor antibody
      • Etdf antibody
      • ETEF 1 antibody
      • ETF antibody
      • TEA domain family member 2 antibody
      • TEAD 2 antibody
      • TEAD-2 antibody
      • TEAD2 antibody
      • Tead2 protein (TEA domain family member 2 (Mapped), isoform CRA_b) antibody
      • TEAD2_HUMAN antibody
      • TEF 4 antibody
      • TEF4 antibody
      • Transcriptional enhancer factor 4 antibody
      • Transcriptional enhancer factor TEF 4 antibody
      • Transcriptional enhancer factor TEF-4 antibody
      see all

    Images

    • Anti-TEA domain family member 2 antibody (ab92279) at 1 µg/ml + Human ileum lysate in RIPA buffer at 35 µg

      Developed using the ECL technique.

      Predicted band size: 49 kDa
      Observed band size: 50 kDa (why is the actual band size different from the predicted?)

    References

    ab92279 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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