Overview

  • Product name
  • Description
    Rabbit polyclonal to TECPR1
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of Human TECPR1.

  • Positive control
    • A375 cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Purification notes
    Purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab92384 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    ELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 130 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.
    • Sequence similarities
      Belongs to the TECPR1 family.
      Contains 1 PH domain.
      Contains 9 TECPR repeats.
    • Domain
      The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns(3)P). While full-length protein is unable to bind PtdIns(3)P in vitro, it is assumed that the binding to the ATG5-ATG12 conjugate exposes the PH domain, allowing the association with PtdIns(3)P (PubMed:22342342).
    • Cellular localization
      Cytoplasmic vesicle > autophagosome membrane. Lysosome membrane. Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.
    • Information by UniProt
    • Database links
    • Alternative names
      • 2210010N04Rik antibody
      • DKFZP434B0335 antibody
      • FLJ23419 antibody
      • FLJ90593 antibody
      • KIAA1358 antibody
      • MGC124730 antibody
      • mKIAA1358 antibody
      • RGD1306873 antibody
      • TCPR1_HUMAN antibody
      • Tecpr1 antibody
      • tectonin beta propeller repeat containing 1 antibody
      • Tectonin beta-propeller repeat-containing protein 1 antibody
      see all

    Images

    • Anti-TECPR1 antibody (ab92384) at 1/100 dilution + A375 cell lysate at 35 µg

      Predicted band size : 130 kDa

    References

    ab92384 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab92384.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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